Viral vector-based gene therapies are large drug-product formulations comprised of protein and nucleic acid components containing over 200,000 atoms. Waters’ liquid chromatography (LC) combined with optical detection (UV, MALS) and mass spectrometry (MS) provide the analytical means to accurately characterize and quantify these heterogeneous structures and their attributes, at both component and intact levels, supporting robust viral vector solutions. Routine measurements include viral titer, aggregate/impurities analysis, viral protein ratios, peptide mapping & modification analysis, encapsidation efficiency, and genome integrity in your viral vector solution workflows.
Biology is variable. Your results shouldn't be.
Comprehensive characterization: Master engineered virus complexity with integrated LC, MS, CDMS, and particle analysis.
Precision at every level: Analyze intact and component-level attributes, from viral titer to encapsulation efficiency.
Reliable performance: Ensure potency, purity and safety with automated, compliance-ready workflows built for productivity.